ialuril® Prefill

Medical device

ialuril® is a unique glycosaminoglycan (GAG) combination therapy with a physico-mechanical action for effective GAG layer restoration1.

 

Click here to find the IFU

Learn more about ialuril
Ialuril Prefill box by IBSA - Sterile solution containing sodium hyaluronate, chondroitin sulphate, and calcium chloride for intravesical instillation

Highlights

Widely studied

Widely studied GAG therapy (30+ studies)2-17

Unique composition

Our unique composition of hyaluronic acid, chondroitin sulphate and calcium chloride provides a mechanism of action (MOA) for increased adherence to the bladder epithelium1

Tolerability

Well-tolerated across a wide range of conditions related to GAG layer disruption2-4,6-9,11,13-15

Clinical trials

Demonstrated re-establishment of the GAG layer in vitro1,18,19 and reduces symptoms of chronic bladder inflammatory conditions related to GAG layer disruption in clinical trials2-17

Multiple administration options

Offers 2 administration options for increased dosing accuracy and patient convenience20

Recommended instillation plan

ialuril® Prefill instillation regime20:
1st month, 1 instillation/week
2nd month, 1 instillation/2 weeks
3rd month onwards, 1 instillation/month

Clinical evidence

Demonstrated efficacy in re-establishing the GAG layer in vitro1,18,19

Reduces symptoms in various chronic bladder inflammatory conditions (related to GAG layer disruption)2-17

Improved patient quality of life and sexual function2-4,6,8,12-14,15,17

Well-tolerated across clinical trials2-4,6-9,11,13-15

ialuril is associated with a low risk of systemic side effects21

A simple instillation regimen20

Can be administered either with a catheter or with the ialuadapter®20

Contact IBSA

Additional resources

Ballerina performing a jump next to a large origami swan structure, symbolizing physical lightness and freedom of movement

Administration via catheter

Ballerina performing a jump next to a large origami swan structure, symbolizing physical lightness and freedom of movement

Administration via ialuadapter

Patient Treatment Diary

Download

Food Diary

Download

Management of recurrent UTIs booklet

Download

Management of non-infectious cystitis booklet

Download

Instructions for use booklet

Download

ialuril patient booklet

Download
Back to the ialuril® product line

If your patient gets any side-effects, please report them. This includes any possible side effects not listed in the package leaflet. You can also report side-effects directly via the Yellow Card Scheme at yellowcard.mhra.gov.uk.

To report a side effect or product complaint to IBSA Pharma please contact IBSA Pharma Ltd on 01923 233466 and medicalinformation.uk@ibsagroup.com.

Ballerina performing a jump next to a large origami swan structure, symbolizing physical lightness and freedom of movement

Section reserved for healthcare professionals

This section contains information intended for healthcare professionals. By continuing, you confirm that you are a healthcare professional authorized to access this content.

Are you a healthcare professional (HCP)?

No, go back

References

  • 1 / Brambilla L, et al. Med Devices (Auckl). 2024;17:47–58.
  • 2 / Damiano R, et al. Eur Urol.2011;59(4):645-51.
  • 3 / De Vita D, et al. Int Urogynecol. 2012;23(12):1707-13.
  • 4 / Cicione A, et al. Can Urol Assoc J. 2014;8(9-10):E721-7.
  • 5 / Ciani O, et al. BMJ Open.2016;6:e009669.
  • 6 / De Vita D, et al. Clinical and Exerimental Obstetrics and Gynecology.2018;45(2):224-228.
  • 7 / Cervigni M, et al. Neurourol Urodynam. 2017;36(4):1178-1186.
  • 8 / Keane J, et al. Eur J Obstet Gynecol Reprod Biol. 2021;256:230-234.
  • 9 / Gacci M, et al. Clin Genitourin Cancer. 2016;14(5):444-449.
  • 10 / Imperatore V, et al. Arch Ital Urol Androl. 2018;90(1):11-14.
  • 11 / Constantini E, et al. Urol Int. 2013;91(1):81-88.
  • 12 / Arslan B, et al. Int Urogyanecol J. 2019;30(11):1857-1862.
  • 13 / Redorta JP, et al. Eur Urol Open Sci. 2021;26:45-54.
  • 14 / Sommariva ML, et al. European Journal of Inflammation. 2014;12(1):177-185.
  • 15 / De Vita D, et al. Gazzetta Medica Italiana - Archivio per le Scienze Mediche.2024;183(5):386-93.
  • 16 / Ko KJ, et al. Sci Rep. 2023;13(1):18256.
  • 17 / Plotti F, et al. 2024;12(12):1190.
  • 18 / Rooney P, et. Front Pharmacol. 2020:11:575043.
  • 19 / Stellavato A, et al. PLoS One. 2019;14(6):e0218475.
  • 20 / ialuril® Prefill Patient Leaflet.
  • 21 / Barua JM, et al. Int Urogynecol J. 2016;27(8):1137-1147.