Learn more about ialuril®

ialuril® contains three active ingredients1:

Hyaluronic acid
800mg/50ml

Plays an important role in protecting the inner lining of the bladder
(the GAG layer)

Calcium chloride
440mg/50ml

Reduces the viscosity (i.e. the thickness) of the ialuril® solution, making it easier to install

Chondroitin sulphate
1000mg/50ml

Binds to the damaged GAG layer barrier and may help to restore it

How does ialuril® work?

A healthy bladder has a good protective barrier

The inner lining (GAG layer) of the bladder functions as a barrier protecting the bladder wall from bacteria and irritants found in urine2.

If the GAG layer becomes damaged, the bladder wall is unprotected

This can cause irritation, inflammation and damage, resulting in pain3.

ialuril® replenishes the GAG layer

ialuril® contains 2 important components that make up the GAG layer: HA and CS4. This enables it to help re-establish the damaged GAG layer5. Therefore, symptoms may be alleviated3,6.

What makes ialuril different?

Combination GAG therapy

ialuril® contains both Hyaluronic acid and Chondroitin Sulphate; a combination which helps to replenish the GAG layer. 5

The only 3 component GAG therapy

Not only is ialuril a combination GAG therapy, it is the only one to contain 3 components. The addition of calcium chloride (CaCl) provides:

Stability:

Calcium (Ca2+) ions help stabilise sodium hyaluronate (HA) and sodium chondroitin sulphate (CS) in the solution7

Persistence:

ialuril is able to adhere to the bladder epithelium due to its mucoadhesive properties8

Functionality:

The combination of all 3 components help to reduce permeability of the bladder’s inner lining whilst maintaining the protective effect of the GAG layer8

Viscosity:

ialuril’s optimised viscosity profile supports ease of instillation9

What comes in the box?

  1. Pre-filled syringe containing 50ml of ialuril®

  2. Plunger to be screwed onto the end of the syringe

  3. Luer-lock adapter for attaching to an intermittent catheter

  4. ialuadapter® to attach to the end of the syringe for catheter-free instillation of ialuril5

How is ialuril® administered?

ialuril® is instilled directly into the bladder either by a catheter, or via the ialuadapter® for catheter-free administration5.

Via a catheter

Any residual urine is drained away and ialuril is passed through the catheter into your bladder. The catheter is then removed, leaving the solution in your bladder.

Via the ialuadapter

You will need to pass urine immediately prior to treatment. The ialuadapter tip is inserted into the urethra and ialuril® is instilled into the bladder through this.

ialuadapter®

The ialuadapter® is a small tip that attaches to the end of the ialuril® syringe. It allows administration of ialuril® without the need for a catheter. It thereby enables treatment to more comfortably continue at home. It comes as standard in each ialuril® box.

  1. The end part fits securely to the ialuril pre-filled syringe.

  2. The ribbed centrepiece provides a secure grip when fitting to the syringe.

  3. The concave isolating collar is made from a flexible material that adapts to the urethral opening, facilitating instillation without leakage.

  4. The radiused tip part is the only part of the device to penetrate into the urethral opening. It is shaped to maximise effectiveness and ease of use5.

How many treatments do I need?

The recommended instillation cycle is as follows5:

Initial phase

1 instillation a week in the 1st month

1 instillation every 2 weeks in the 2nd month

Maintenance phase

1 instillation a month in the following months until stable remission of the symptoms, or as prescribed by your doctor

The solution contained in the syringe must be kept in the bladder for as long as possible. At least 30 minutes is recommended.